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Based on reports that the use of nonsteroidal anti-inflammatory drugs (NSAIDs)may reduce the risk for Alzheimer's disease(AD),we studied the cross-sectional relation between NSAID use and the risk for AD in a population-based study of disease and disability in older people.After controlling for age,education,gender,and use of benzodiazepines,we found a relative risk(RR)for AD of 0.38(0.15 to 0.95)when comparing NSAID users(n= 365)to NSAID non-users(n=5,893).To address confounding by indication or contraindication,we compared NSAID users with a subset of NSAID non-users who were using topical medication foe ear,eye,or dermatologic conditions (n=365).In this comparison,the adjusted RR for AD was 0.54(0.16 to 1.78). These findings are compatible with a possible protective effect of NSAIDs on the risk for AD. |
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